Comments About 2017 Life Science Transactions and Outlook for 2018

Yuval Horn, Horn & Co Law Offices

It has been an exciting year in 2017, with many significant factors affecting growth and development, along with several transactions that we have been involved in. I will focus on the five most interesting in our practice.


Data, Data, Data

Big data, analytics and artificial intelligence have presented new opportunities in the life science and medical device sectors. Dozens of new companies have formed, with most focusing on analysis of publicly and privately sourced information and some engaging in “deep learning”. Data is driven from an abundance of sources: genetic testing, medical procedures, imaging tests (X-rays, MRIs), and user-generated sources (compliance).

Data is being used or offered for multiple related areas. Developers of technology and caregivers are seeking access to data for analytics for treatment (personalised medicine); for diagnosis; and for the drug development process and patient population identification. Some companies are developing deep-learning capabilities in order to expedite treatment and advice. Medical institutions are involved, to an increasing extent, in the provision of their stored data to companies, for the technology development. Such data allows companies to analyse their technologies and verify the underlying assumptions, but also to analyse the data and create novel means of diagnosis. Organisations are searching for devices and means to connect and optimise caregiving. They are involved in the integration of data-driven solutions. Automated review and response of clinical data, including comparison and analysis of existing data, will allow for a more efficient and quicker outcome, for the benefit of patients, institutions and payers. Finally, centralised treatment of data is evolving, as well as development of data platforms, accessible across jurisdictions and platforms, which allow for online information relating to the status of treatment and use by parallel caregivers.

The data that is being licensed or used by technology development companies needs to be anonymised, and requires the approval of Internal Review Boards (formed under the Declaration of Helsinki) and relevant informed consents. In addition, the use and transfer of data raises multiple issues relating to cybersecurity, privacy and regulation.

In Europe, the General Data Protection Regulation (GDPR) (Regulation (EU) 2016/679) will become enforceable on 25 May 2018. This will strengthen and unify data protection standards across the European Union, and, unlike the Directive of 1995, will be binding within the EU member countries. The GDPR prescribes that consent by the provider of data must be clear, explicit, distinguished from any other matter and provided in an intelligible and easily accessible form. Such consent must also be as easy to withdraw as it is easy to be given. Data subjects will be entitled to receive confirmation from the data controller as to whether or not (and where) personal data concerning them is being processed, and for what purpose. Increased enforcement and penalties, and the strengthening of the conditions for consent of personal data processing are expected to raise new issues in 2018.

Data, its collection, protection and commercialisation, as well as the development of new technologies based on data, will undoubtedly be key in our respective practices in 2018 as well. Or, according to Accenture’s 2017 survey, “74% of Life Sciences executives believe A.I. will result in significant change and even completely transform their industry within three years … 74% of life sciences executive agree that their org is entering digital industries that have yet to be defined” (available at

Commodification of Services

With the world becoming smaller, companies’ managements becoming experienced and buyers being selective, young companies are reaching out to major CROs for a wider array of services, with increasing success. Services, which were provided in the past to large companies only, are now being sought for and provided to smaller companies desiring to conduct the most professional trials from the start. There is still something to be desired in terms of fees and services, but the direction is clear. Experienced management focuses on value creation by developing professional building blocks by way of outsourcing, where required, in order to verify success in future scrutiny and diligence reviews in strategic transactions. Technology transfer companies of research institutions are increasingly active in the provision of services to others, thus allowing younger companies to enjoy the breadth of experience and innovation from the earliest stages. These are beneficial outcomes for the companies, and, in turn to the patients. The expedited, more efficient manner in which companies may operate mean less time to market. It allows investors to verify that their funds are well spent, attempting to maximise each payment milestone.

The increasing role of the consumers and patient advocacy groups

Consumers and patients are seeking a greater role in the treatment process, including as a result of the abundance of data and the desire to control costs. Patient advocacy groups are funding research, and positively affecting the focus of the research community. With increasing funding to and support of pharma by these groups, we should see an increasing number of dedicated companies seeking to develop treatment for often rare diseases. The cure of such diseases has not only a significant upside, but, more importantly, address an unmet medical need by a small group of patients, which may have been overlooked without such support.


Immunotherapy took an additional step forward with the FDA approval, in August 2017, of the CAR-T treatments. This therapy includes the collection of cells, treatment in vitro and infusion into the same patients. Riding this impressive wave, Kite Pharma was sold to Gilead for US$11.9 billion in August, 2017. This novel therapy opens a wide array of opportunity for companies developing new models of immunotherapy, targeting different types of cancer and the transformation of the treatment process and logistics. It would be safe to assume that this purchase, which adds to the 2015 purchase of Ccam Biotherapeutics Ltd by Merck, and significant multibillion-dollar big pharma collaborations in this area will lead to more good news in 2018. 

Transactions (the Israeli experience)

At this time, we do not have the updated global 2017 statistics to compare with 2016. However, from our standpoint, 2017 was a rocky, interesting year for Israeli and Israeli technology-based companies, which were parties to significant transactions. Kite Pharma Inc, whose technology included Israeli intellectual property, was acquired by Gilead for $11.9 billion. Teva Pharmaceuticals Ltd, the flagship of Israeli pharma, has faced a significant crisis, which has involved the sale of assets in excess of $2.5 billion. Neuroderm Ltd was acquired by Mitsubishi Tanabe for $1.1 billion. Apax Partners purchased an affiliate of Syneron Medical Ltd for $400 million. While Pharma buy-side remains selective, we expect 2018 to present additional significant acquisitions.

Investments by Israeli venture capital funds in life sciences companies have increased and significantly expanded abroad, indicating that the funds have sufficient capital to target both the numerous local opportunities and many opportunities outside of Israel. According to the IVC Research Center, Israeli life sciences companies raised $1.2 billion, 41 percent more than the $850 millon raised in 2016. Additional investments by non-Israeli funds and strategic investors and pharma companies – from the US but also from China and Japan – should be a continuing trend in 2018.

As the 2018 series of funds emerge, this tendency is expected to increase, with various factors, such as tax, managerial capacities, proximity to market, being key.


In addition, in 2017 the tendency of Israeli investors to license technologies from non-Israeli institutions increased. As the Israeli experience and success have increased, and as the standards of licensing are maintained worldwide, excellent research and novel ideas have no boundaries. We expect this to continue in 2018.

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